Through its action on the pituitary, danazol indirectly reduces estrogen production by lowering the output of follicle-stimulating hormone and luteinizing hormone. There is also evidence that danazol binds to sex hormone receptors in target tissues, thereby exibiting anabolic, antiestrognic and weakly androgenic activity. With higher doses, amenorrhea generally occurs after about 6 weeks of therapy; ovulation and cyclic bleeding returns to normal 60—90 days after therapy is discontinued. Danazol is used to treat endometriosis because it causes atrophy of ectopic endometrial tissue, which relieves symptoms completely. It also decreases the growth rate of abnormal breast tissue, making it useful in fibrocystic breast disease. Heriditary angioedema is an inherited disorder characterized by a deficiency in C1 esterase inhibitor (C1 INH), a serum inhibitor of the activated first component of complement. Danazol increases circulating levels of C1 INH and therby increases C4 of the complement system, which also is deficient in hereditary angioedema. Consequently, danazol prevents attacks of hereditary angioedema in both males and females. The exact mechanism by which danazol increases C1 INH is not known. Danazol does not possess any progestogenic activity, and does not suppress normal pituitary release of corticotropin, or release of cortisol by the adrenal glands.
SARMs ( Selective Androgen Receptor Modulators ) are performance enhancers which have been used in competitive sports for some time. According to the many users of SARMS in the world of steroids, they are used because they are oral in nature and they target androgen receptors in the body effectively. The fact that they have to be ingested is a plus for Selective Androgen Receptor Modulators, since they take a short time to reach the bloodstream. SARMS are the most highly abused steroids in the world of sports and since they are cheaper and more effective a lot of drug companies are making them for the black market. According to users, the problem with other steroids is that they have their own unique limitations as they will cause the fluctuation of testosterone levels in the bloodstream. Androgenic effects of using SARMS are noticed immediately after they have been used. It is for this reason that it has been used for the treatment of osteoporosis in women. SARM is one of the few of its kind not to cause liver damage in its users. Most oral steroids have been modified to protect them from being damaged by the liver when it is being ingested and most of them cause a lot of liver problems due to this.