Finally, this study clearly shows that different outcomes plateau at different time points. For ex. the significant improvements in blood cholesterol and triglycerides (lipids) reached a plateau after 3-4 years of TRT, while the decrease in HbA1c was progressive and statistically significant up to five years of testosterone treatment. Importantly and interestingly, the reductions in waist circumference and body weight (and percentage change in body weight) were statistically significant at the end of each year compared to the previous year over the first five years, and even at the end of the sixth year compared to fifth year. This is an unusual and remarkable finding, as obesity interventions (both drugs and lifestyle changes) commonly are most effective the first year, and thereafter progressively lose their efficacy. 57-59 As this 6-year long study demonstrates, testosterone treatment excels in this regard. Let’s hope in the near future this information will reach doctors working with patients who are sedentary, obese and suffer from cardio-metabolic complications.
Other significant adverse effects of testosterone supplementation include acceleration of pre-existing prostate cancer growth in individuals who have undergone androgen deprivation; increased hematocrit , which can require venipuncture in order to treat; and, exacerbation of sleep apnea .  Adverse effects may also include minor side-effects such as acne and oily skin, as well as, significant hair loss and/or thinning of the hair, which may be prevented with 5-alpha reductase inhibitors ordinarily used for the treatment of benign prostatic hyperplasia , such as finasteride .  Exogenous testosterone may also cause suppression of spermatogenesis , leading to, in some cases, infertility.  It is recommended that physicians screen for prostate cancer with a digital rectal exam and prostate-specific antigen (PSA) level before starting therapy, and monitor PSA and hematocrit levels closely during therapy. 
If you think you may have Low T symptoms or are suffering from Andropause (Hypogonadism), don't hesitate to contact a Hormone Therapy Physician at one of our male hormone replacement clinics today. You can get tested for Low T with a fast, easy lab test and start treatment right away with a prescription. Find a Testosterone Doctor & Clinics for hormone testing, diagnoses and treatment. Our Testosterone Therapy Doctors , Urologists and Endocrine Physicians have successfully treated over 18,000 patients. Our Testosterone Therapy Centers utilize the most progressive hormone treatment protocols backed up with training from the Mayo Clinic® and Cleveland Clinic®. Fill out the Quick Info Request Form to speak to a Testosterone Specialist and to receive the best pricing for Testosterone Injections and other hormone replacement medications like HCG and HGH Human Growth Hormone.