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Another intriguing difference lies in the effect on Sex Hormone Binding Globule (SHBG). SHBG is a naturally produced glycoprotein that binds to testosterone, making it unavailable for purposes such as building muscle. StanoGen is able to cause a lowering of SHBG and therefore free up more testosterone within the body. However, due to oral StanoGen having to first pass through the liver (where SHBG is produced), whereas injectable StanoGen doesn’t have to complete this first pass, oral StanoGen has a greater effect on lowering SHBG levels , and freeing up more testosterone.