Antiviral drug, especially effective against herpes simplex virus (the virus that causes lesions of the skin and mucous membranes) and herpes zoster (the virus that causes disease of the central and peripheral nervous system with the emergence of bubble rash along the sensory nerves).
Acyclovir is an analog of a purine nucleoside dezoksiguanidina, the normal component of the DNA (deoxyribonucleic acid – part responsible for the transfer of genetic information of the cell nucleus).
The similarity of structures and acyclovir acyclovir dezoksiguanidina allows to interact with the viral enzymes, which leads to an interruption of viral replication. After the introduction of acyclovir in herpes diseased cell under the influence of thymidine released virus aiiklovir converted to acyclovir monophosphate which enzymes of the host cell is transformed into acyclovir diphosphate. and then to the active form of acyclovir-triphosphate, which blocks viral DNA replication (intracellular mechanism DNA complex division, resulting in the multiplication of viruses). The drug acts selectively on viral DNA synthesis. DNA of the host cell replication (human cells) to acyclovir triphosphate has almost no effect.
When administered acyclovir absorbed only partially (approximately 20%). The half-life (the time for which the output ‘/ zyaozy drug) by ingestion and administered intravenously for about 3 hours. Provided mainly kidneys unchanged, partly in the form of a metabolite (exchange product). In renal insufficiency, the half-life is greatly increased (up to hours).